An In-Depth Analysis of Liver Fat Quantification Using 5T MRI: A Comparative Study with 1.5T MRI MRS-PDFF

Motivation: Nonalcoholic fatty liver disease (NAFLD) is an escalating health issue, necessitating precise noninvasive measurement of hepatic steatosis. Goal(s): To evaluate the feasibility and accuracy of 5T magnetic resonance spectroscopy (MRS) for in vivo liver fat quantification. Approach: The study utilized phantoms with controlled fat content and 20 volunteers, comparing proton density fat fraction (PDFF) values measured by 5T MRS against those from 1.5T MRS. Results: The 5T MRS demonstrated strong consistency with 1.5T measurements, validating its potential in clinical diagnostics despite technical challenges associated with ultra-high-field MRI applications. Impact: The study's validation of 5T MRS for liver fat quantification could enhance diagnostic precision for liver conditions, influencing clinical practices and guiding future technological advancements in MRI diagnostics.