Alteration in asymmetry of glymphatic system function in patients with Self-limited epilepsy with centrotemporal spikes

Motivation: Self-limited epilepsy with centrotemporal spikes (SLECTS) is the most prevalent type of idiopathic childhood epilepsy. However, the underlying pathophysiologic mechanisms of SLECTS is largely unknown. Goal(s): Studies on the glymphatic system function in SLECTS patients may contribute to better understanding of the associated mechanisms. Approach: Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) was used to evaluate the glymphatic system function. Results: The SLECTS patients exhibited altered DTI-ALPS index. Altered DTI-ALPS index were more severe in ipsilateral than in the contralateral hemisphere. Moreover, RSLECTS (Right SLECTS ) and LSLECTS (Left SLECTS) patients exhibited different change patterns of the glymphatic system. Impact: This study indicating that the glymphatic system may be a separate system in the left and right hemispheres. Patients with RSLECTS and LSLECTS exhibited different pattern of glymphatic system changes. Our research may contribute to elucidating the pathophysiologic of SLECTS.