Short-term Performance of Single Bolus r-SAK Prior to PCI in ST-Segment Elevation Myocardial Infarction by Cardiac Magnetic Resonance Imaging

Motivation: Compared with primary percutaneous coronary intervention (PPCI), it is not known whether patients with ST-elevation myocardial infarction (STEMI) benefit from thrombolysis prior to PCI within 120 minutes of symptom onset. Goal(s): This study was to compare the short-term performance between STEMI patients with and without a single bolus recombinant staphylokinase (r-SAK) prior to PCI by Cardiac Magnetic Resonance (CMR) imaging. Approach: The global and segmental [mainly focusing on LGE+ segment (transmural extent >50%)] CMR parameters were compared between r-SAK group and control group. Results: Patients can benefit from thrombolysis prior to PCI with better myocardial function and smaller extent of edema. Impact: This study investigated the short-term advantages of adjunctive thrombolysis with r-SAK for STEMI patients undergoing PCI. A single bolus r-SAK intravenously prior to PCI for STEMI improves myocardial function and reduces the extent of edema.