The Feasibility of Synthetic MRI in Monitoring NPC with Clival Invasion Changes During Radiation Treatment

Motivation: Complications from radiotherapy in nasopharyngeal carcinoma impact patient quality of life, necessitating methods to determine the optimal radiation dose for patients. Goal(s): To evaluate Synthetic MRI's ability to monitor clival invasion and its changes during treatment in nasopharyngeal carcinoma patients. Approach: T1, T2 and PD values of clivus were acquired before treatment, at radiation doses of 6420cGy and 7062cGy, and were compared with each other. Results: Prior to treatment, the clival T1 values in clival invasion patients were higher than those without clival invasion. No difference was found in Quantitative values between the radiation dose reached 6420cGy and 7062cGy. Impact: Synthetic MRI can assess clival invasion in nasopharyngeal carcinoma and its changes during radiation treatment, potentially enabling the evaluation of the optimal radiation dose for patient.