Quantitative multiparametric UTE-MRI sequences for early cartilage degeneration corresponding to biochemical components——an in vivo study

Motivation: The detection of early cartilage degeneration by UTE-MRI has been demonstrated in many in vitro experiments but lacks validation in in vivo studies. Goal(s): To explore the feasibility of UTE-MRI quantitative imaging in the diagnosis of early cartilage degeneration in vivo, compare the diagnostic efficacy of various sequences and explore their corresponding pathological and biochemical basis. Approach: Volunteers were recruited preoperatively to perform MRI for comparison with postoperative pathology. Results: UTE-MRI values have shown greater in vivo diagnostic value for early cartilage degeneration compared to conventional T2 and T1ρ values, and mainly reflect different aspects of cartilage degeneration. Impact: Validating the clinical utility of UTE-MRI in vivo for diagnosing early cartilage degeneration contributes to the early detection and intervention of articular cartilage degeneration in osteoarthritis patients.