Associations between time-dependent diffusion MRI parameters and WHO/ISUP grade of clear cell renal cell carcinoma

Motivation: OGSE-MRI provides more information on kidney cancer prognosis, metastasis possibility, specific survival rate in the future. Goal(s): To explore whether parameters derived from OGSE can demonstrate microstructure in clear cell renal cell carcinomaApproach: Patients suspected of ccRCC who underwent diffusion-weighted imaging were employed to quantify the time-dependent diffusion MRI-based microstructural parameters cell diameter (D), intracellular volume fraction (vin), cellularity, and diffusivities (Dex). Results: ccRCC with high WHO/ISUP grade show higher cellularity and vin, while lower D and Dex parameters. Impact: The OGSE MRI parameters correlates with pathologic grades and demonstrates promise for characterizing renal carcinoma.