Assessment of individualised cortical gyrification in infants with congenital heart disease
Motivation: Congenital heart disease (CHD) is common and associated with impaired early brain development. Goal(s): To assess whether preoperative cortical Gyrification Index (GI) in infants with CHD deviates from the normal trajectory. Approach: GI trajectories were normatively-modelled using reference control MRI data from 320 healthy infants, enabling calculation of GI Z-scores for the whole brain and frontal, occipital, parietal, temporal, cingulate and insular cortices for 130 infants with CHD, after accounting for sex, postmenstrual age at scan and days since birth at scan. Results: Mean GI Z-scores were significantly lower for the whole brain and all cortical regions in infants with CHD (All PFDR<0.018)Impact: Global and regional brain gyrification is reduced in infants with critical or severe CHD in the neonatal period, prior to cardiac surgery, and these individualised measures of cortical folding are significantly associated with cerebral oxygen delivery in the neonatal period.
Authors
- A. David Edwards (ORCID: https://orcid.org/0000-0003-4801-7066)
- Andrew Chew (ORCID: https://orcid.org/0000-0002-4344-2015)
- Kuberan Pushparajah (ORCID: https://orcid.org/0000-0003-1541-1155)
- Alexandra F. Bonthrone (ORCID: https://orcid.org/0000-0001-5487-5564)
- Manu Kumar (ORCID: https://orcid.org/0009-0003-8479-3561)
- Siân Wilson (ORCID: https://orcid.org/0000-0003-4617-3583)
- Paul Cawley (ORCID: https://orcid.org/0000-0002-4353-0656)
- Christopher Kelly (ORCID: https://orcid.org/0000-0002-1246-844X)
- Serena J. Counsell (ORCID: https://orcid.org/0000-0002-8033-5673)
- Daniel Cromb (ORCID: https://orcid.org/0000-0002-9814-8841)
- Jonathan O’Muircheartaigh (ORCID: https://orcid.org/0000-0002-8033-6959)
- Ralica Dimitrova (ORCID: https://orcid.org/0000-0002-6903-7990)
- Mary Rutherford (ORCID: https://orcid.org/0000-0003-3361-1337)
- Joseph V. Hajnal (ORCID: https://orcid.org/0000-0002-2690-5495)
- John Simpson
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2387
- Primary Topic
- Cardiac Arrhythmias and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00