Associations between small vessel function and progressive white matter injury in CADASIL using advanced 7T MRI
Motivation: Impaired blood flow velocity and pulsatility on 7T MRI are associated with white matter injury in cerebral small vessel disease (cSVD) cross-sectionally, but it is unclear whether it relates to injury progression. Goal(s): To assess if small vessel dysfunction is associated with markers of progressive white matter injury in monogenic cSVD. Approach: Small vessel function was measured on 7T MRI in monogenic cSVD. White matter injury (white matter hyperintensities, peak-skeletonized mean diffusivity) was measured with 3T MRI on baseline and two-year follow-up. Results: There were no associations between small vessel dysfunction and white matter injury progression in monogenic cSVD. Impact: Whole-brain white matter injury progression cannot be explained by small vessel function. Local white matter injury progression might be linked with small vessel function and should be assessed in the future with voxelwise studies.
Authors
- Jeroen C.W. Siero (ORCID: https://orcid.org/0000-0001-5079-2868)
- Nikki Dieleman (ORCID: https://orcid.org/0000-0003-1841-0924)
- Geert Jan Biessels (ORCID: https://orcid.org/0000-0001-6862-2496)
- Anna Kopczak (ORCID: https://orcid.org/0000-0002-5037-2342)
- Alberto De Luca (ORCID: https://orcid.org/0000-0002-2553-7299)
- Stanley Pham (ORCID: https://orcid.org/0000-0001-7477-2116)
- Jaco J.M. Zwanenburg (ORCID: https://orcid.org/0000-0002-4282-5719)
- Hilde van den Brink (ORCID: https://orcid.org/0000-0003-3094-0274)
- Naomi Vlegels (ORCID: https://orcid.org/0000-0001-7420-9411)
- Benno Gesierich (ORCID: https://orcid.org/0000-0003-2842-7105)
- Marco Duering (ORCID: https://orcid.org/0000-0003-2302-3136)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2215
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00