Hippocampal subfield and amygdala nuclei gray matter volume reduction in early-onset schizophrenia

Motivation: Assessing the Gray matter volume changes in the hippocampal subfield and amygdala nuclei will help to understand the underlying mechanisms of the disease. Goal(s): To assess hippocampal subfield and amygdala nuclei volume changes in patients with early-onset schizophrenia (EOS). Approach: High-resolution 3D T1 images were acquired in both the control (34) and the EOS (31). Hippocampal subfield and amygdala nuclei segmentation was performed using FreeSurfer. Results: Volume reduction in the bilateral basal, para-laminar, and right lateral amygdala nuclei, as well as molecular layer, subiculum, para-subiculum, CA4 hippocampal subfield. Impact: The gray matter volume reduction of the hippocampus subfield and amygdala nuclei maybe associated with poor clinical outcomes in EOS.