Evidence of impaired dACC glutamate modulation under task-specific motor control in obsessive compulsive disorder (OCD) using 1H fMRS
Motivation: The neurobiological mechanisms of poor top-down motor control in OCD are not well understood. Goal(s): Our goal was to investigate neurobiological differences in glutamate modulation across different motor/inhibitory control responses in OCD compared to healthy controls. Approach: 1H fMRS was conducted in adolescents with OCD and healthy controls. Results: Task-specific impairments to the dACC glutamate modulation were observed in OCD compared to healthy controls. Impact: These results providing compelling evidence towards characterizing neurosignaling changes in OCD pathophysiology.
Authors
- Vaibhav A. Diwadkar (ORCID: https://orcid.org/0000-0001-6458-6969)
- Dalal Khatib
- Usha Rajan
- Rebecca Neill (ORCID: https://orcid.org/0000-0001-7445-8856)
- Jeffrey A. Stanley (ORCID: https://orcid.org/0000-0003-2355-480X)
- Phil Easter
- Jillian Eichstaedt
- Julia Bellamy
- David Rosenberg
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1830
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00