Evaluation of bone marrow fat content and fatty acid composition using quantitative MRI combined with metabonomics in diabetic rabbits
Motivation: Bone marrow is a key target for diabetes mellitus. Goal(s): Quantitative assessment of fat content in lumbar bone marrow and trabecular microstructural changes in alloxan-induced diabetics rabbits. Approach: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence (IDEAL-IQ), micro computed tomography (Micro-CT), and gas chromatography-mass spectrometry (GC-MS) were employed. Results: IDEAL-IQ and GC-MS techniques are capable of detecting changes in fat content and variations in fatty acid composition during the early stages of diabetic bone marrow. Impact: The fat content and fatty acid composition in the bone marrow plays an important role in bone metabolism in diabetic patients.
Authors
- Yunfei Zha (ORCID: https://orcid.org/0000-0002-8714-7472)
- Hu Lei (ORCID: https://orcid.org/0000-0002-7927-9053)
- Weiyin Vivian Liu (ORCID: https://orcid.org/0000-0002-7917-7612)
- Tian Zhang (ORCID: https://orcid.org/0000-0002-9891-7399)
- Yuchen Yan (ORCID: https://orcid.org/0000-0003-3359-4012)
- Yufan Gao
- Ziyan Fei
- Yan Wang (ORCID: https://orcid.org/0009-0002-2584-9337)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/5032
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00