Association between Glymphatic Function and Peripheral Inflammation in Different Motor Subtypes of Parkinson Disease

Motivation: The association between glymphatic system and peripheral inflammation has not been well studied. Goal(s): Our study aimed to explore the relationship between glymphatic system and peripheral inflammation in PD patients and PD subtypes, and their link to motor symptoms. Approach: We used DTI to calculate the DTI-ALPS index, a non-invasive measure of glymphatic function, and evaluated the association between the DTI-ALPS index and clinical parameters using multiple linear regression. Results: Our study revealed a correlation between peripheral inflammation and glymphatic dysfunction in PD, particularly in TD subtype. Furthermore, the association between peripheral inflammation and clinical severity was observed in PD and PIGD patients. Impact: This study provides new insights into the pathophysiology of PD and potential therapeutic options.