Feasibility Assessment of Measuring ADC of Meningeal Lymphatic Vessels using High-Resolution MUSE DWI and PROPELLER DWI

Motivation: Is it possible to water diffusion be measured in meningeal lymphatic vessels (MLVs)?Goal(s): Diffusion-weighted MRI is employed to assess the circulatory condition of MLVs, eliminating the need for MRI with contrast agent administration, which typically requires monitoring for over 4 hours. Approach: Water diffusion measurements in MLVs were conducted using MUSE DWI and PROPELLER DWI, which offer low image distortion and high resolution. Results: Our results indicate that MLVs were clearly visible on high spatial resolution DWI and ADC maps, and the ADC values of MLVs are higher than those of GM and WM but lower than CSF. Impact: Since evaluating the circulatory condition of meningeal lymphatic vessels takes over 4 hours by contrast agent injection, our study investigates the feasibility of assessing the ADC of meningeal lymphatic vessels using high-resolution MUSE DWI and PROPELLER DWI.