Time-Frequency Multiplexed Wideband Array Beam-Forming Enhances Thermal Magnetic Resonance Theranostics of Brain Tumors

Motivation: Thermal magnetic resonance theranostics combines diagnostic MRI with targeted thermal therapy with an integrated radiofrequency applicator. Precise RF dosimetry is crucial for real-time treatment planning. Goal(s): Our goal is to evaluate a time-frequency multiplexing wideband RF beamforming method for precise targeting of small and large deep-seated brain tumors for Thermal Magnetic Resonance theranostics. Approach: We employed a multi-vector field shaping algorithm for optimizing RF channel settings of the RF applicator. Results: With time-frequency multiplex excitations, we achieved precise SAR10g targeting in the tumor volume while minimizing RF exposure to healthy tissues. Our study advances thermal magnetic resonance theranostics efficacy promising improved outcomes. Impact: Our approach of utilizing horse-shoe shaped RF applicator comprised of wideband SGBT dipole antenna can be conveniently adapted to individual patient's tumor position and geometry while maintaining the efficiency and quality of RF heating for ThermalMR theranostics of brain tumors.