Multi-parametric Quantitative Magnetic Resonance Imaging Phantom

Motivation: Currently there is no qMRI phantom that simultaneously reproduces the many contrasts that are present in white matter. Goal(s): The goal of this work is to characterize a single multiparametric qMRI phantom that exhibits diffusion, magnetization transfer and MET2 properties. Approach: Aqueous MTF and PVP were combined in varying concentrations and evaluated with both NMR and MRI. Results: A homogenous, multiparametric qMRI phantom was created with an array of tissue relevant parameters: T2L ranging from 71.9-183 ms, T2s ranging from 13.6-17.7 ms, fs ranging from 0.118-0.177, T1free ranging from 1479-1919 ms and fm ranging from 0.053-0.109. Impact: A multiparametric phantom allows for improved quality assurance analysis, as well as sequence development by allowing for multiple contrasts to be evaluated simultaneously. Ultimately providing a sample that is controlled, yet more akin to what occurs in biological samples.