Advancing 3D DWI Imaging with the 3D Radial-EPI(RAZER) Trajectory

Motivation: Non-Cartesian sampling offers advantages in motion robustness and speed, crucial in 3D DWI. Goal(s): We aimed to improve 3D DWI using RAZER trajectory to improve the 3D DWI imaging with reducing scan time while preserving imaging quality. Approach: We implemented 3D DW RAZER sequence with integrated radial and EPI sampling and conducted 3D DWI studies in a phantom and human carotid arteries. Results: The RAZER DWI sequence offered a clearer depiction of the carotid arterial structure and reliable ADC measurements without geometric distortion when compared to 2D ss-DW EPI, all within a scan time of less than two minutes. Impact: This study introduces a motion-robust 3D DWI with faster imaging capabilities, potentially improving vulnerable plaque identification. It addresses conventional DWI limitations, providing a valuable resource for the detection of possible events and improved patient outcomes in ischemic stroke.