Hyperdynamic CSF flow is related to ventricular volumes and jugular venous flow in adolescents with congenital heart disease (CHD)

Motivation: Enlarged CSF volumes have been reported in children with congenital heart disease (CHD), and have been linked to neurodevelopmental outcome, but the origin of these enlarged CSF volumes is not yet known. Goal(s): To examine the link between CSF flow, arteriovenous flow and CSF volumes in order to improve our understanding of the observed changes in CSF volume. Approach: Phase contrast MRI of the cerebral aqueduct, carotid arteries and jugular veins was combined with 3D anatomical MRI for segmentation of the CSF spaces. Results: CHD children show hyperdynamic CSF flow, which is linked to enlarged 3rd ventricle volumes and venous flow. Impact: An improved understanding of the link between heart defects and brain development and hydrodynamics may help to foster improved development and outcome for children with CHD in future.