Intraoperative Precision Sampling of Tumor Microenvironments based on 7T MRSI: A pipeline development
Motivation: Molecular and pathological diagnosis requires fresh tissues. It is important to achieve precise sampling and preservation of the tumor is for maintaining the tumor integrity. MRSI can accurately identify tumor hotspots and can be used for obtaining high quality samples. Goal(s): Develop MRSI pipeline for precise intraoperative tumor sampling. Approach: We processed 7T MRSI metabolic ratio maps and identified the tumor hotspots. We then correlated them with their quantitatively analyzed metabolic profiles. Results: We were able to achieve high quality tumor samples based on our 7T MRSI maps. Impact: Due to high resolution 7T metabolic ratio maps we could identify and define tumor hotspots which resulted in precise tumor sampling. We were also able to preserve the tissue specimens and obtain high quality results.
Authors
- Cornelius Cadrien (ORCID: https://orcid.org/0000-0002-0341-2209)
- Siegfried Trattnig (ORCID: https://orcid.org/0000-0003-1623-3303)
- Claus Brenner (ORCID: https://orcid.org/0000-0002-6459-0682)
- Wolfgang Bogner (ORCID: https://orcid.org/0000-0002-0130-3463)
- Julia Furtner (ORCID: https://orcid.org/0000-0001-8258-3681)
- Barbara Kiesel (ORCID: https://orcid.org/0000-0003-0939-9831)
- Thomas Roetzer-Pejrimovsky (ORCID: https://orcid.org/0000-0001-8875-7304)
- Lisa Irina Wadiura (ORCID: https://orcid.org/0000-0002-9227-461X)
- Gilbert Hangel (ORCID: https://orcid.org/0000-0002-3986-3159)
- Matthias Preusser (ORCID: https://orcid.org/0000-0003-3541-2315)
- Georg Widhalm (ORCID: https://orcid.org/0000-0001-6014-0273)
- Sagar Acharya (ORCID: https://orcid.org/0009-0005-9816-2415)
- Philipp Lazen (ORCID: https://orcid.org/0000-0002-9952-3084)
- Sara Huskić
- Ahmet Azgın
- Gunda Köllensperger
- Karl Rössler (ORCID: https://orcid.org/0000-0002-9249-8082)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4699
- Primary Topic
- Advanced X-ray Imaging Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00