Myelin water fraction mapping of in-vivo and ex-vivo human brains at 3T and 7T
Motivation: Multi-echo gradient-echo (mGRE) MRI enabled non-invasive quantification of myelin water fraction (MWF) of the human brain. Goal(s): The MWF may depend on field strength that changes the T2* decay and the results need to be verified by histological staining. Approach: We performed mGRE-based MWF on in-vivo and ex-vivo human brain at high resolution and revealed the accuracy of the measurements using histological staining at both 3T and 7T. Results: The MWF-derived from 7T was systematically higher than those from 3T and the in-vivo and ex-vivo measurements showed good agreement. The MWF at 3T and 7T both demonstrated good correlations with myelin basic protein. Impact: These findings indicated the MWF mapping could reliably depict the myelin content in the human brain, although the measurement were field-strength dependent.
Authors
- Yao Shen (ORCID: https://orcid.org/0000-0002-4393-2794)
- Zhiyong Zhao (ORCID: https://orcid.org/0000-0002-1432-0430)
- Zuozhen Cao (ORCID: https://orcid.org/0000-0001-8119-6436)
- Qinfeng Zhu (ORCID: https://orcid.org/0000-0001-8038-0274)
- Dan Wu (ORCID: https://orcid.org/0000-0002-9303-5821)
- Jing Zhang (ORCID: https://orcid.org/0000-0001-8427-3134)
- Sihui Li (ORCID: https://orcid.org/0000-0003-3918-0486)
- Keqing Zhu (ORCID: https://orcid.org/0000-0003-2864-3043)
- Guojun Xu
- Yiqi Shen
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2175
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00