Correlations between 5-ALA fluorescence and 7T MRSI in gliomas: Preliminary observations
Motivation: Heterogeneity in gliomas represents a clinical and diagnostic issue. 5-ALA fluorescence used for intraoperative tumor delineation is different depending on the tumor type. Understanding the dysregulations in the heme pathway using 7T MRSI could help understanding metabolic heterogeneity in tumors. Goal(s): Identifying 7T MRSI metabolites useful for investigating mechanisms of 5-ALA fluorescence and preoperative tumor characterization. Approach: We retrospectively correlated 5-ALA fluorescence from clinical reports to metabolic ratios from 7T MRSI scans in a cohort of 23 patients. Results: 5-ALA correlated with the Gln/tCr ratio (r2=0.597), which also correlated with the tumor grade. Impact: Using 7T MRSI and 5-ALA, we improve guidance for neurosurgeons to resect aggressive tumor hotpots. Furthermore, 7T MRSI could be useful for in vivo studies of metabolic disturbances involved in 5-ALA activation.
Authors
- Cornelius Cadrien (ORCID: https://orcid.org/0000-0002-0341-2209)
- Karl Roessler (ORCID: https://orcid.org/0000-0002-9249-8082)
- Siegfried Trattnig (ORCID: https://orcid.org/0000-0003-1623-3303)
- Wolfgang Bogner (ORCID: https://orcid.org/0000-0002-0130-3463)
- Julia Furtner (ORCID: https://orcid.org/0000-0001-8258-3681)
- Barbara Kiesel (ORCID: https://orcid.org/0000-0003-0939-9831)
- Thomas Roetzer-Pejrimovsky (ORCID: https://orcid.org/0000-0001-8875-7304)
- Lisa Irina Wadiura (ORCID: https://orcid.org/0000-0002-9227-461X)
- Gilbert Hangel (ORCID: https://orcid.org/0000-0002-3986-3159)
- Matthias Preusser (ORCID: https://orcid.org/0000-0003-3541-2315)
- Georg Widhalm (ORCID: https://orcid.org/0000-0001-6014-0273)
- Sagar Acharya (ORCID: https://orcid.org/0009-0005-9816-2415)
- Philipp Lazen (ORCID: https://orcid.org/0000-0002-9952-3084)
- Sara Huskić
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1824
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00