Amide Proton Transfer Magnetic Resonance Imaging of Type 2 Diabetes Mellitus: A Preliminary Study

Motivation: APT imaging has been used to study neurodegenerative diseases,T2DM is also known to be associated with cognitive decline and brain structural changes,so, it is interesting to explore the cerebral metabolic alternation of T2DM. Goal(s): This study investigated the feasibility of APT to monitor the condition of T2DM patients. Approach: Twenty T2DM patients and Twenty age- and sex-matched healthy controls (HCs) underwent conventional MR and APT scanning,The image analysis of APT was performed by 3D Slicer software. Results: The results showed that the APT values in the left temporal white matter of T2DM patients were lower and significantly different from healthy controls. Impact: By APT technique, temporal lobe white matter APT signal values were found to be lower in T2DM patients than in healthy controls, which can provide more information on cerebral metabolic changes in T2DM patients.