Fast full-brain relaxometry in the clinic using MR-STAT
Motivation: This is the first work assessing quantitative values (T1 and T2) from Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) as a fast relaxometry technique in clinical setting. Goal(s): To assess MR-STAT as viable option for fast relaxometry in the clinic. Approach: We applied MR-STAT to investigate the quantitative T1 and T2 values of brain tissue at 3T in a heterogeneous cohort of 50 subjects (10 healthy volunteers, mixed-pathology 40 patients). Results: Quantitative values in normal appearing brain tissue were comparable to earlier literature. Furthermore, individual case examples (glioma, multiple sclerosis) confirmed the ability to discern pathological tissue in T1 and T2 values. Impact: Voxel values in clinical MRI are subjective. Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) quickly quantifies MR tissue properties and gives voxels quantitative values. This work demonstrates MR-STAT as fast relaxometry technique in a clinical population and assesses quantitative values.
Authors
- Anja G. van der Kolk (ORCID: https://orcid.org/0000-0002-8267-8848)
- Federico D’Agata (ORCID: https://orcid.org/0000-0001-9432-0248)
- Jan Willem Dankbaar (ORCID: https://orcid.org/0000-0003-4646-9587)
- Beyza Köktaş
- Cornelis A. T. van den Berg (ORCID: https://orcid.org/0000-0002-5565-6889)
- Stefano Mandija (ORCID: https://orcid.org/0000-0002-4612-5509)
- Vera C. Keil (ORCID: https://orcid.org/0000-0001-8699-3506)
- Tom J. Snijders (ORCID: https://orcid.org/0000-0003-0857-081X)
- Alessandro Sbrizzi (ORCID: https://orcid.org/0000-0003-3276-4542)
- Jordi P. D. Kleinloog (ORCID: https://orcid.org/0000-0001-5861-9656)
- Oscar van der Heide (ORCID: https://orcid.org/0000-0002-8451-525X)
- Hanna Liu
- Jeroen Hendrikse (ORCID: https://orcid.org/0000-0001-6384-6140)
- Sarah Jacobs
- Martin Bastiaan Schilder (ORCID: https://orcid.org/0009-0003-4058-4928)
- Evert‐Jan Vonken (ORCID: https://orcid.org/0000-0003-0982-0323)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2169
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00