Long-Term Outcomes Prediction in Diabetic Heart Failure with Preserved Ejection Fraction: A Cardiac Magnetic Resonance Imaging Study

Motivation: While diabetes mellitus has a high prevalence in HFpEF and being associated with poorer outcomes, limited data are available on the cardiac MRI features of diabetic HFpEFGoal(s): We aimed to explore imaging features including tissue characterization and myocardial deformation in diabetic HFpEF patients by MRI, and investigate its prognostic value for adverse outcomesApproach: Feature-tracking derived strain and strain rates parameters and myocardial fibrosis were assessed by cardiac MRI in patients with diabetic HFpEFResults: Diabetic HFpEF patients were characterized by more impaired strains and myocardial fibrosis. Tissue characterization and global longitudinal strain obtained from MRI-FT provided incremental value for risk predictionImpact: Our findings suggested that MRI-derived variables especially GLS played a crucial role in risk stratification and predicting worse prognosis in diabetic HFpEF, which could assist in identifying high-risk patients and guide therapeutic decision making.