Total tumor apparent diffusion coefficient histogram parameters identify ISS stages in multiple myeloma with diffuse infiltration

Motivation: Is there any difference in the ttADC histogram parameters at different ISS stages in multiple myeloma patients with diffuse infiltration visually?Goal(s): The goal was to explore the difference in ttADC histogram parameters and clinical indicators in multiple myeloma patients with diffuse infiltration at different ISS stages. Approach: The ttADC histogram parameters were obtained by sketching the lesions of the whole body on WB-DWI images using MRTTL software. Results: Age, hemoglobin, creatinine, and ttADC_5% were different at different ISS stages. Impact: Diffuse infiltration is generally thought to be associated with a poorer prognosis for MM patients. Our study shows that although all patients have diffuse infiltration, different ttADC histogram parameters may result in different prognosis.