Validation of diffusivity analysis along the perivascular space (ALPS) index as a biomarker for vascular cognitive impairment and dementia
Motivation: To test the validity of the ALPS index as a biomarker for VCIDGoal(s): To test our hypothesis that ALPS index is an independent biomarker for the cognitive decline in cSVD. Approach: Participants from MarkVCID consortium underwent baseline and follow-up MRI examinations and clinical evaluations of cognitive functionResults: We found the baseline ALPS index was correlated with the existing biomarkers of cSVD and VCID, and was independently associated with the baseline cognitive performanceImpact: Our study provides the clinical validation of the ALPS index as a sensitive and independent biomarker for the cognitive function of cSVD related VCID.
Authors
- Charles DeCarli
- Brian T. Gold (ORCID: https://orcid.org/0000-0002-6958-7095)
- Steven Cen (ORCID: https://orcid.org/0000-0002-7859-8909)
- Mohamad Habes (ORCID: https://orcid.org/0000-0001-9447-5805)
- Bruce Fischl (ORCID: https://orcid.org/0000-0002-2413-1115)
- Hanzhang Lu (ORCID: https://orcid.org/0000-0003-3871-1564)
- Lara Stables
- Arvind Caprihan (ORCID: https://orcid.org/0000-0002-4810-359X)
- Xingfeng Shao (ORCID: https://orcid.org/0000-0002-4130-6204)
- Giuseppe Barisano (ORCID: https://orcid.org/0000-0001-5598-1369)
- Kay Jann (ORCID: https://orcid.org/0000-0003-3574-0538)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Kristin Schwab (ORCID: https://orcid.org/0000-0001-5723-9109)
- Steven Mark Greenberg (ORCID: https://orcid.org/0000-0003-1792-8887)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- Herpreet Singh (ORCID: https://orcid.org/0000-0003-3797-7301)
- John M. Ringman (ORCID: https://orcid.org/0000-0001-5429-0777)
- André van der Kouwe (ORCID: https://orcid.org/0000-0002-2754-6594)
- Karl G. Helmer (ORCID: https://orcid.org/0000-0002-5113-6843)
- Xiaodan Liu (ORCID: https://orcid.org/0000-0002-3387-2177)
- Clandia L. Satizabal
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2636
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00