Influence of temporal resolution in determining pharmacokinetic parameters from CAIPIRINHA-Dixon-TWIST-VIBE DCE-MRI for breast lesions

Motivation: The quantitative parameters from dynamic contrast-enhanced (DCE) MRI can improve the diagnosis in characterizing breast cancer. Goal(s): However, the influence of temporal resolution in determining pharmacokinetic parameters is still unclear. Approach: In this study, we aimed to evaluate influence of scan temporal resolution on pharmacokinetic parameters and performance in diagnosing breast cancer. Results: The results demonstrated that as temporal resolution decreases, Ktrans, kep, and ve increase, and there were no significant differences in AUCs in diagnosing breast cancer for any of the parameters. Impact: This study transforms breast cancer diagnosis by validating the influence of temporal resolution in determining pharmacokinetic parameters. It encourages exploration into broader adaptations, aiming to provide the accurate pharmacokinetic quantitative parameters in the diagnosing cancer and assessing prognosis across multi-institutions.