Multi-center, multi-vendor validation of PDFF and T1 mapping in an optimized PDFF-T1 phantom
Motivation: Chemical-shift-encoded (CSE)-based proton-density fat-fraction (PDFF) is a highly validated biomarker of liver fat. T1 mapping has been proposed as a biomarker of hepatic fibrosis. However, the reproducibility of PDFF and T1 in the setting of concomitantly varying fat and T1 is poorly understood. Goal(s): To validate the reproducibility of CSE-based PDFF and MOLLI-based T1 mapping with concomitantly varying fat and T1. Approach: We conducted a four-center, four-vendor validation study using a quantitative PDFF-T1 phantom. Results: CSE-based PDFF had good reproducibility, although with increased bias and variability at long T1 values. The reproducibility of MOLLI-based T1 was affected substantially by the presence of fat. Impact: CSE-based PDFF demonstrated good reproducibility across four centers/vendors, at both 1.5T and 3T. Increased T1 and increased PDFF led to reduced MOLLI-based T1 reproducibility. This multi-center multi-vendor PDFF-T1 phantom validation approach may enable evaluation of improved quantitative MRI methods.
Authors
- David R. Rutkowski (ORCID: https://orcid.org/0000-0002-1168-5004)
- Hung Do
- Won C. Bae (ORCID: https://orcid.org/0000-0003-2616-0339)
- Jitka Starekova (ORCID: https://orcid.org/0000-0002-4285-3090)
- Suraj D. Serai (ORCID: https://orcid.org/0000-0002-8821-0971)
- Vadim Malis (ORCID: https://orcid.org/0000-0002-0426-1457)
- Diego Hernando (ORCID: https://orcid.org/0000-0002-0016-0317)
- Ananth J. Madhuranthakam (ORCID: https://orcid.org/0000-0002-5524-7962)
- Sebastian Weingärtner (ORCID: https://orcid.org/0000-0002-0739-6306)
- Jean H. Brittain (ORCID: https://orcid.org/0000-0002-1314-8114)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Takeshi Yokoo (ORCID: https://orcid.org/0000-0002-5092-6931)
- Sujoy Mukherjee (ORCID: https://orcid.org/0000-0001-9783-7664)
- Sheng Qing Lin
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4996
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00