T2 relaxometry of foot muscles in young patients with Charcot-Marie-Tooth disease: comparison between centres and scanner vendors
Motivation: Current clinical use of quantitative MRI biomarkers for the assessment of neuromuscular disease is limited by accuracy and reliabilityGoal(s): To develop a robust processing strategy for multi-vendor muscle-water T2 mapping (T2m) in foot muscleApproach: A multi-component CPMG extended phase graph signal model was used to determine T2m and apparent fat fraction (ffa) in fat-infiltrated foot muscle using maximum likelihood estimationResults: Stable estimates of foot muscle T2m and ffa were obtained in patients with Charcot-Marie-Tooth disease and healthy controls, at baseline and 1 year follow up. In patients, T2m and ffa were both elevated at each time pointImpact: T2m and ffa obtained from CPMG images using extended phase graph modelling and maximum likelihood estimation may be sensitive measures of neuromuscular pathology
Authors
- Alexander Martin Rossor (ORCID: https://orcid.org/0000-0003-4648-2896)
- Peg Nopoulos (ORCID: https://orcid.org/0000-0001-8810-1903)
- Tiffany Grider (ORCID: https://orcid.org/0000-0002-2236-9218)
- Michael E. Shy (ORCID: https://orcid.org/0000-0001-8460-6971)
- Mariola Skorupinska
- John S. Thornton (ORCID: https://orcid.org/0000-0003-3248-8437)
- Laura Matilde
- Evelin Milev (ORCID: https://orcid.org/0000-0002-7129-1824)
- Daniel R. Thedens (ORCID: https://orcid.org/0000-0002-4704-3185)
- Menelaos Pipis (ORCID: https://orcid.org/0000-0003-0511-6515)
- Carolynne Doherty (ORCID: https://orcid.org/0000-0003-0129-3573)
- Jasper M. Morrow (ORCID: https://orcid.org/0000-0001-6879-8539)
- Shawna Feely (ORCID: https://orcid.org/0000-0003-1689-1963)
- Stephen Wastling (ORCID: https://orcid.org/0000-0003-4648-9932)
- Tina Banks
- Luke O’Donnell (ORCID: https://orcid.org/0000-0001-9514-1516)
- Amy McDowell (ORCID: https://orcid.org/0000-0002-4886-6191)
- Tarek Yousry (ORCID: https://orcid.org/0000-0003-3295-0628)
- Riccardo Zuccarino (ORCID: https://orcid.org/0000-0002-8481-7899)
- Francesco Muntoni (ORCID: https://orcid.org/0000-0002-9102-5232)
- Emma Nicolaisen
- Sachit Shah
- D.G.T. Thomas
- K Stephens
- Mary Reilly
- Nick Zafeiropoulos
- Howard Paige
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/5033
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00