A Docker-based Ensemble Pipeline for Tractogram with High-throughput, Reproducible and Comprehensive Mapping of White Matter Fibers (DEPTH)

Motivation: The complex whole brain connectome is underlined by white matter (WM) fibers featuring both long and short-range connections. Most existing protocols are tailored to trace long-range fibers, incapable of comprehensively tracing all fibers including both long and short-range fibers. Goal(s): To achieve comprehensive mapping of whole-brain WM fibers in a unified framework including specifically high-fidelity tractogram of short-range fibers. Approach: We developed DEPTH, a Docker-containerized pipeline extending advanced short-range fiber tracing. Results: DEPTH offers high-throughput, reproducible and comprehensive tractogram of both long and short-range WM fibers. The Docker-based containerization ensures cross-platform usability and versatility without complex setup and configuration. Impact: High-throughput, reproducible and comprehensive whole-brain white matter fibers across multisite datasets could now be traced by our software.