Feasibility of 3D Reduced-FOV Multi-shot Isotropic DWI in Optic Nerves

Motivation: Conventional 2D DWI sequences suffer from several disadvantages, therefore hindering the clinical visual assessment of optic nerves. Goal(s): This study aims to enable a 3D reduced-FOV multi-shot isotropic DWI sequence for optic nerves DWI and verify its feasibility. Approach: The pulse sequence and corresponding reconstruction algorithm of 3D reduced-FOV 2-shot isotropic DWI was developed to achieve effective and accurate reconstruction of optic nerves. Results: Preliminary results have shown the feasibility of our method in depicting the optic nerves with high resolution and high fidelity, therefore potentially benefiting the clinical applications of optic nerves DWI. Impact: 3D reduced-FOV multi-shot isotropic optic nerves DWI shows superior advantages of high resolution and high fidelity compared with other conventional DWI sequences, which should be further investigated and applied for clinical applications of optic nerves.