Macromolecular fraction and magnetization exchange rate acquired with UTE-MRI differ in the tibial bone of diabetic rats: a feasibility study
Motivation: Increased risk of fractures in patients with type-2 diabetes mellitus (T2DM) despite higher average bone mineral density is unexplained with routine diagnostic tools like DEXA and CT. Goal(s): This study aimed to examine the feasibility of using ultrashort echo time (UTE) magnetization transfer (MT) modeling to detect the potential differences between T2DM and normal rats. Approach: The macromolecular fraction (MMF) and proton exchange rate (kab) from UTE-MT modeling on the tibial bone of Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats were compared. Results: There was a significant difference in MMF and kab measures between the two groups. Impact: The MMF and kab measures can detect potential bone alternations related to T2DM which may help to better understand the pathogenesis of T2DM bone fractures.
Authors
- Christine B. Chung (ORCID: https://orcid.org/0000-0002-0821-5458)
- Yajun Ma (ORCID: https://orcid.org/0000-0003-0830-9232)
- Dina Moazamian (ORCID: https://orcid.org/0000-0002-8815-4535)
- Jiang Du
- Eric Yao Chang (ORCID: https://orcid.org/0000-0003-3633-5630)
- Soo Hyun Shin (ORCID: https://orcid.org/0000-0003-1875-2908)
- Eddie Fu
- Saeed Jerban (ORCID: https://orcid.org/0000-0001-6450-2892)
- Arya Suprana (ORCID: https://orcid.org/0009-0009-7946-0360)
- Hamidreza Shaterian Mohammadi (ORCID: https://orcid.org/0009-0006-4749-437X)
- Nigel Calcutt
- Alireza Tyarani
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4892
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00