Altered Interactive Dynamics of Neurofluids in Cerebral Small Vessel Disease
Motivation: While changes of neurofluid dynamic has been observed in CSVD, the potential inter-correlations between them are still unclear. Goal(s): Our goal was to demonstrate the potential interactive dynamics of neurofluids including the parenchyma perfusion, the glymphatic pathway, and the intracranial CSF in CSVD patients. Approach: Parenchyma perfusion was assessed with pASL, glymphatic dynamics was assessed with DTI- ALPS, and CSF volume of ventricles was also quantified. Results: The interactive dynamics of neurofluids of CSVD patients is significantly altered compared with that of normal elderly. Impact: Disruption of neurofluid dynamics may play an important role in the pathophysiology of CSVD.
Authors
- Wenzhen Zhu (ORCID: https://orcid.org/0000-0001-6252-9450)
- Yuanyuan Qin (ORCID: https://orcid.org/0000-0002-0673-3200)
- Wenhao Zhu
- Tian Tian (ORCID: https://orcid.org/0000-0003-0634-0455)
- Shiqi Yang (ORCID: https://orcid.org/0009-0004-1286-4524)
- Jiaxuan Zhang (ORCID: https://orcid.org/0009-0000-3382-3415)
- Yuanhao Li (ORCID: https://orcid.org/0000-0002-6938-5012)
- Chengxia Liu (ORCID: https://orcid.org/0000-0002-5579-9230)
- Shun Zhang
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2624
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00