Fast Single-Point Macromolecular Proton Fraction Mapping using a 0.3 T MRI System

Motivation: Quantifying myelin content in 0.3 T low-field MRI presents a challenge owing to prolonged imaging times and a low signal-to-noise ratio. Goal(s): The study aimed to validate the practical feasibility of macromolecular proton fraction (MPF) mapping in the brain using a 0.3 T MRI system. Approach: A phantom study with protein samples and an in vivo investigation were conducted. Results: The study findings indicate a robust correlation between 0.3 T MPF in brain tissue, MPF at 3.0 T, and previously reported MPF at 0.5 T. Impact: The fast single-point MPF mapping using a 0.3 T MRI exhibited the capacity to accurately measure brain MPF in a clinically feasible timeframe, providing a valuable tool for assessing myelin content.