The long-term cerebral change of patient transformed from mildly into severely emotional problem after multiple COVID-19 infections: 3-6 months

Motivation: It was unclear that if the brain function would be changed after multiple COVID-19 infections when the psychological burden incremented. Goal(s): To evaluate the long-term brain brain change of the patients who transformed from mildly emotional problem after the first COVID-19 infection into severely one after multiple infections. Approach: The patients with mildly emotional abnormality after once infection (control group) and others transformed from mild into severe abnormality after multiple COVID infections (patients group) were included. The parameters derived from BOLD and DTI were compared after 3-6 months. Results: The patients group had a decreased FA and increased ALFF in some brain areas. Impact: The abnormalities in these brain areas could help clinicians to understand the potential machine of the transformation of mild emotion problem into severe emotion problem after another COVID infection.