The relation between sleep indices and indices for brain interstitial fluid dynamics by MRI and the effects of orexin antagonists: a FLUID study.
Motivation: The motivation is to investigate the relationship between sleep and interstitial fluid dynamics influenced by the administration of lemborexant, a dual orexin receptor antagonist. Goal(s): The goal is to identify changes in indices of interstitial fluid dynamics related to sleep before and after the administration of lemborexant. Approach: ALPS-index, Ktrans by DSC method, and choroid plexus volume were assessed as indicators of interstitial fluid dynamics. Results: The sleep indexes on a night were found to correlate with the ALPS-index measured in the evening before that night's sleep. In multiple regression analysis, the ALPS-index was lower when sleep parameters were poor at baseline. Impact: The sleep indexes on a night were found to correlate with the ALPS-index measured the evening before. The evaluation of the ALPS-index before and after lemborexant administration revealed that the baseline sleep status played a role in improving the index.
Authors
- Toshiki Nakane (ORCID: https://orcid.org/0000-0002-0383-2879)
- Hirohito Kan (ORCID: https://orcid.org/0000-0002-5688-2685)
- Shinji Naganawa
- Nobuyasu Ichinose (ORCID: https://orcid.org/0000-0001-6580-5086)
- Akihiro Fujimoto (ORCID: https://orcid.org/0000-0002-0075-0800)
- Rei Nakamichi (ORCID: https://orcid.org/0000-0001-6933-0954)
- Ippei Okada
- Toshiaki Taoka (ORCID: https://orcid.org/0000-0001-9227-0240)
- Yuki Kogo (ORCID: https://orcid.org/0000-0002-8120-3971)
- Rintaro Ito (ORCID: https://orcid.org/0000-0002-7971-043X)
- Junko Kikuta (ORCID: https://orcid.org/0000-0003-1324-8614)
- Seiko Miyata (ORCID: https://orcid.org/0000-0002-1144-5676)
- Norio Ozaki
- Kunihiro Iwamoto (ORCID: https://orcid.org/0000-0003-3868-3372)
- Koji Kamagata (ORCID: https://orcid.org/0000-0001-5028-218X)
- Shigeki Aoki (ORCID: https://orcid.org/0000-0003-2821-0651)
- Kazushige Ichikawa
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4919
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00