MRI-based Cerebral Palsy Early Diagnosis in Infants with Periventricular White Matter Injury aged 6 to 24 months: A Multireader Multicase Study

Motivation: Early diagnosis of cerebral palsy in infants with periventricular white matter injury is crucial for rehabilitation. Goal(s): To develop and externally validate a MRI-based model to predict CP in infants with PWMI aged 6 to 24 months, and evaluate the diagnostic performance of the model using the MRMC analysis. Approach: In this study, A MRI-based multivariable logistic regression model was develop at one center , and was validated at the three centers, and to evaluate the diagnostic performance of the model using the MRMC analysis. Results: The model showed both excellent predictive performance in the multicenter cohorts and high diagnostic performance in MRMC analysis. Impact: Our model is a reliable and reproducible tool for diagnosis of CP in infants with PWMI aged 6 to 24 months.