Cervical Cancer and Paracancerous Tissue ATPw combined with DWI to predict Parametrial infiltration: An Preliminary Study

Motivation: Cervical cancer(CC) is one of the most common gynecological malignancies. Parametrial infiltration (PMI) is considered a decisive factor in the treatment of patients with CC. Goal(s): This study aimed to investigate the potential of Amide proton transfer-weighted (APTw) in predicting PMI of CC, and to further evaluate whether the APTw parameters of paracancerous tissue can add diagnostic value to diffusion-weighted MRI of CC. Approach: 81 participants underwent pelvic MRI , including APTw MRI ,and takes measurements. Results: The results showed that the APTw values ,especially in paracancerous tissues, could be used to efficiently distinguish PMI of cervical cancer. Impact: APTw values ,especially in paracancerous tissues, could be used to efficiently distinguish PMI of cervical cancer. which can provide additional information to improve the results of diffusion-weighted MRI, thereby assisting further clinical decision-making and improving patient prognosis.