Diffusion-relaxation correlation spectroscopic imaging for evaluating change of white matter of X‑linked adrenoleukodystrophy

Motivation: Diffusion-relaxation correlation spectroscopic imaging (DR-CSI) may be a useful tool for advancing our understanding of X-linked adrenoleukodystrophy (ALD) and its impact on white matter. Goal(s): To measure the changes in white matter composition and microenvironment in ALD patients using DR-CSI. Approach: Recruited four groups of participants. DR-CSI was utilized with a multi-parametric approach, considering both diffusion and relaxation properties to provide a comprehensive view of the tissue microenvironment. Data analysis was performed to quantify changes in white matter composition. Results: In the context of ALD, DR-CSI can effectively differentiate between the diverse tissue compartments by examining diffusion and relaxation characteristics. Impact: This is of significant relevance for the diagnosis and treatment strategies of this rare disease. Moreover, the study results offer information regarding differences among ALD phenotypes, which holds potential value for individualized treatment and management development.