Investigating brain correlates of neural plasticity with visual-motor sequence learning: Preliminary observations using 3.0T MAGNUS

Motivation: To investigated whether white matter microstructural changes after adaptive short-term training can be detected in a limited sample size with a high-performance gradient system that allows for increased sensitivity to underlying brain micro-architecture. Goal(s): Demonstrate that with task complexity and short-term training, the dynamic-location-specific neuroplastic changes can be detected. Approach: Advanced structural and functional MRI sequences in <60-min examination with a pre- and post-design paradigm were used in a high-performance head gradient system that allows for increased sensitivity to the underlying brain micro-architecture. Results: In this pilot study microstructural changes were noted on a group basis underlying primary motor and sensorimotor cortices. Impact: This study highlights the role of dynamic brain processes following short term visual motor sequencing learning (VMSL). The adult brain preserves dynamic characteristics that are altered by short-term learning experiences that can be detected with dMRI.