Linking inter-individual differences in brain structure to post-COVID fatigue

Motivation: Identify individuals at risk of developing post-COVID fatigueGoal(s): Propose a "vulnerability" hypothesis of post-COVID fatigueApproach: A multi-center, prospective, longitudinal studyResults: The GMV in frontal-limbic regions may serve as potential neural underpinnings that identify individuals at risk of developing post-COVID fatigueImpact: Our findings emphasized the essential role of frontal-limbic system in the development of post-COVID fatigue, which will improve public health interventions by allowing for the early identification of individuals at risk of persistent post-COVID fatigue and facilitating subsequent neuromodulation treatment.