T1-Weighted MP2RAGE Optimisation for Neonates at 7T
Motivation: There is currently no high contrast structural T1-weighted protocol available for neonatal imaging at ultrahigh field (7T), as the longer T1 relaxation times make existing protocols optimized for older subjects unsuitable. Goal(s): To produce submillimeter T1-weighted images for neonates at 7T in a clinically feasible scan time. Approach: We optimised a T1-weighted MP2RAGE protocol using the genetic algorithm for constrained optimisation while accounting for transmit field inhomogeneities. Results: 3D whole-brain images with 0.65-0.8mm isotropic resolution were acquired in under 6-7 minutes from 3 infants. Quantitative T1 maps were produced using an in-house fitting algorithm. Impact: We describe the first neonatal optimised MP2RAGE protocol for acquiring high-contrast submillimeter-resolution images with full-brain coverage that are relatively insensitive to transmit field inhomogeneities.
Authors
- Shaihan Malik (ORCID: https://orcid.org/0000-0001-8925-9032)
- Maria Deprez (ORCID: https://orcid.org/0000-0002-2799-6077)
- Alena Uus (ORCID: https://orcid.org/0000-0001-5796-2145)
- Tomoki Arichi (ORCID: https://orcid.org/0000-0002-3550-1644)
- Philippa Bridgen (ORCID: https://orcid.org/0009-0008-8051-8139)
- Joseph V. Hajnal (ORCID: https://orcid.org/0000-0002-2690-5495)
- David W. Carmichael (ORCID: https://orcid.org/0000-0001-9972-0718)
- Raphaël Tomi‐Tricot (ORCID: https://orcid.org/0000-0002-6149-9154)
- Beya Bonse
- Pierluigi Di Ciò (ORCID: https://orcid.org/0000-0002-0457-9449)
- Ayse Sila Dokumaci
- Ines Tomazinho
- Aiman Mahmoud
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2365
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00