Edited MRS of the Infant Brain on 28 Scanners
Motivation: The Healthy Brain and Child Development (HBCD) study is a longitudinal, multi-vendor, multi-site study of early brain development, which will enroll ~7,500 infants. HBCD includes MRS within the imaging protocol. Goal(s): The goal of this abstract is to present HBCD MRS pilot data, and identify any vendor and site differences in MRS data quality and measured metabolite concentrations. Approach: HBCD pilot MRS data were successfully acquired on 28 scanners, and analyzed using Osprey 2.5.0, to examine vendor and site differences. Results: ANOVA results show minimal vendor and site differences which is encouraging for such a large-scale multi-site, multi-vendor study. Impact: HBCD is an NIH-funded multicenter study of brain development across the first decade of life. It is the largest ever study to incorporate MRS. In this abstract, we present in vivo data demonstrating MRS performance across vendor and site.
Authors
- Ralph Noeske (ORCID: https://orcid.org/0000-0002-6193-366X)
- Muhammad G. Saleh (ORCID: https://orcid.org/0000-0001-6921-112X)
- Kimberly B. Weldon (ORCID: https://orcid.org/0000-0003-4349-9916)
- Helge J. Zöllner (ORCID: https://orcid.org/0000-0002-7148-292X)
- Borjan Gagoski (ORCID: https://orcid.org/0000-0003-3777-2621)
- Aaron T. Gudmundson (ORCID: https://orcid.org/0000-0001-5104-0959)
- Georg Oeltzschner (ORCID: https://orcid.org/0000-0003-3083-9811)
- William T. Clarke (ORCID: https://orcid.org/0000-0001-7159-7025)
- Richard A.E. Edden (ORCID: https://orcid.org/0000-0002-0671-7374)
- Steve C. N. Hui (ORCID: https://orcid.org/0000-0002-1523-4040)
- Saipavitra Murali‐Manohar (ORCID: https://orcid.org/0000-0002-4978-0736)
- Yulu Song (ORCID: https://orcid.org/0000-0002-4416-7959)
- Christopher W. Davies‐Jenkins (ORCID: https://orcid.org/0000-0002-6015-762X)
- Jessica L. Wisnowski (ORCID: https://orcid.org/0000-0002-4039-8362)
- M. Dylan Tisdall (ORCID: https://orcid.org/0000-0002-0454-3112)
- Jens T. Rosenberg
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2393
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00