Multi-vendor Multi-site accelerated high-resolution T1ρ mapping with retrospective and prospective compressed sensing reconstruction

Motivation: High-resolution T1ρ mapping is desired to improve the early diagnosis of diseases such as osteoarthritis; however, it suffers from long acquisition times. Goal(s): To accelerate high-resolution T1ρ mapping using compressed-sensing reconstruction in a multi-site multi-vendor setting. Approach: We standardized the T1ρ imaging protocol between three sites using three MR platforms (GE/Philips/Siemens). Accelerated high-resolution T1ρ mapping with accelerator factors (AF) ranging 8-12 were performed using both retrospective and prospective downsamplings with compressed-sensing reconstruction. Results: The coefficients-of-variation between reference and accelerated maps were <5% for all sites. Reliable high-resolution T1ρ mapping of the whole knee can be acquired within 7 mins. Impact: Standardization of the acquisition and reconstruction of accelerated high-resolution T1ρ mapping across sites and MR platforms will greatly facilitate its future use in clinical trials and clinical practice, significantly improving diagnosis and evaluation of responses to interventions/treatments for OA.