Glymphatic dysfunction in non-dialysis, hemodialysis and peritoneal dialysis patients with ESRD is associated with cognitive decline

Motivation: The glymphatic function has not yet been explored in non-dialysis,HD and PD patients with ESRD. Goal(s): Our goal was to explore the pattern of glymphatic function in ESRD patients and its relationship with cognitive decline. Approach: Diffusion tensor imaging along the perivascular space (DTI-ALPS) index methods was used to investigating brain glymphatic dysfunction in ESRD patients with non-dialysis, HD and PD patients using. The relationship between Montreal Cognitive Assessment (MoCA) and changes in DTI-ALPS index was measured. Results: Compared with HD and PD, ESRD patients with non-dialysis showed lower DTI-ALPS index.Changed DTI-ALPS index associated with cognitive decline in ESRD patients with non-dialysis. Impact: Our findings reveal a greater degree of aberrant glymphatic functionality in ESRD patients with non-dialysis than HD and PD, which may offer new insights to the effectiveness of dialysis treatment.