Plasma Concentration as a Proxy for Perilymph Drug Levels: Preclinical and Clinical Dexamethasone Measures with a Long-Acting Formulation for Precise Delivery to the Round Window Membrane
Sustained release dexamethasone from SPT-2101 precisely delivered at the round window provides prolonged and durable estimated perilymph concentrations in clinical subjects.
Authors
- Jafri Kuthubutheen (ORCID: https://orcid.org/0000-0003-2550-2472)
- Jeremy G. Turner
- Charles J. Limb (ORCID: https://orcid.org/0000-0003-3109-1550)
- Alan C. Foster
- Signe Erickson
- Jeffrey D. Sharon (ORCID: https://orcid.org/0000-0003-4892-5064)
- Alec N. Salt (ORCID: https://orcid.org/0000-0003-3462-9256)
- Kathleen Cogan Farinas
- Benson T. Jung (ORCID: https://orcid.org/0000-0002-9527-9096)
- Hugo Peris
- Eugene de Juan
- Amanda Henton
Institutions
- The University of Western Australia (AU)
- University of California, San Francisco (US)
- Changi General Hospital (SG)
- Turner Consulting Group (United States) (US)
- Spiral Foundation (US)
Publication Details
- Journal
- Otology & Neurotology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1097/mao.0000000000004336
- Citations
- 3
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.74