Genome‐wide methylation profiling of maternal cell‐free <scp>DNA</scp> using methylated <scp>DNA</scp> sequencing (<scp>MeD</scp>‐seq) indicates a placental and immune‐cell signature
MeD-seq can detect (novel) genome-wide placental DNA methylation marks and determine fetal sex in maternal cfDNA. Our results indicate a placental and immune-cell contribution to the pregnancy-specific cfDNA methylation signature. This study supports future research into maternal cfDNA methylation.
Authors
- Ruben Boers (ORCID: https://orcid.org/0000-0002-3377-2897)
- Régine P.M. Steegers‐Theunissen (ORCID: https://orcid.org/0000-0002-4353-5756)
- Marjolein M. van Vliet (ORCID: https://orcid.org/0000-0001-5476-037X)
- Joachim Boers (ORCID: https://orcid.org/0000-0001-5016-4829)
- Sam Schoenmakers (ORCID: https://orcid.org/0000-0002-0316-6159)
- Olivier J. M. Schäffers (ORCID: https://orcid.org/0000-0003-0147-020X)
- Lotte E. van der Meeren (ORCID: https://orcid.org/0000-0002-4537-5645)
- Joost H. Gribnau (ORCID: https://orcid.org/0000-0001-5645-4691)
Institutions
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1111/eci.14363
- Citations
- 5
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 5.55