An Organoid Model for the Therapeutic Effect of Hyperthermic Intraperitoneal Chemotherapy for Colorectal Cancer
In vitro hyperthermic perfusion demonstrates that the inhibition rate of mitomycin C, both alone and in combination with cisplatin, surpasses that of the combination of mitomycin C with 5-fluorouracil and oxaliplatin. In clinical practice, the combination of mitomycin C and cisplatin can be regarded as the optimal choice for HIPEC in CRC.
Authors
- Weihao Deng (ORCID: https://orcid.org/0009-0001-2287-0061)
- Zexin Chen
- Keli Yang
- Jian Cai (ORCID: https://orcid.org/0000-0001-5687-2009)
- Xiangwei Wu (ORCID: https://orcid.org/0000-0002-3897-6629)
- Duo Liu (ORCID: https://orcid.org/0000-0002-0674-0558)
- Yu Zhu (ORCID: https://orcid.org/0000-0002-6928-4027)
- Yuanxin Zhang (ORCID: https://orcid.org/0000-0002-9761-7933)
- Huaiming Wang (ORCID: https://orcid.org/0000-0003-3126-4618)
- Xing Xu (ORCID: https://orcid.org/0009-0002-8686-7459)
- Jianqiang Lan
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1245/s10434-024-16469-1
- Citations
- 3
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 1.72