Elevated serum interferon-α2 associates with activity and flare risk in juvenile-onset systemic lupus erythematosus
Serum IFN-α2 levels associate with disease activity and can predict ongoing and future flares in jSLE. These findings suggest that quantification of IFN-α2 may support risk stratification and disease monitoring in these patients.
Authors
- Christian M. Hedrich (ORCID: https://orcid.org/0000-0002-1295-6179)
- Yanick Joseph Crow (ORCID: https://orcid.org/0000-0001-7211-7564)
- Kukatharmini Tharmaratnam (ORCID: https://orcid.org/0000-0002-8255-9822)
- David Hunt (ORCID: https://orcid.org/0000-0003-4230-0207)
- Michael W. Beresford (ORCID: https://orcid.org/0000-0002-5400-9911)
- Eve Smith (ORCID: https://orcid.org/0000-0002-8371-7597)
- Valentina Natoli (ORCID: https://orcid.org/0000-0001-6733-4134)
- Andrea Jorgensen (ORCID: https://orcid.org/0000-0002-6977-9337)
Institutions
- University of Liverpool (GB)
- Université Paris Cité (FR)
- Istituto Giannina Gaslini (IT)
- Alder Hey Children's NHS Foundation Trust (GB)
- MRC Centre for Regenerative Medicine (GB)
- UK Dementia Research Institute (GB)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Institute of Genetics and Cancer (GB)
- Institut des Maladies Génétiques Imagine (FR)
- University of Genoa (IT)
- University of Edinburgh (GB)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1093/rheumatology/keae643
- Citations
- 3
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Alder Hey Children's NHS Foundation Trust
- National Institute for Health and Care Research
- Agence Nationale de la Recherche
- European League Against Rheumatism
- Versus Arthritis
- LUPUS UK
- Medical Research Council