Multi-parametric MRI for Evaluating Variations in Structure, Function, and Metabolites in Acute Kidney Injury Induced by Ischemia Reperfusion
Motivation: There is lack of a comprehensive MRI technique to comprehensively detect the acute kidney injury (AKI) induced by ischemia reperfusion injury (IRI). Goal(s): We aimed to develop the mpMRI for diagnosis of AKI induced by ischemia reperfusion IRI. Approach: The IRI-AKI model of 40-minutes ischemia in rats were established, and mpMRI is conducted at 0, 1, 3, 7, 14, and 28 days. Several MRI indexes signal and their diagnosis performance were compare, respectively. Results: Multi-parametric MRI may shows comprehensive variations in IRI-AKI, and amine-CEST may exhibits the highest accuracy for diagnosis of IRI-AKI. Impact: This may provide guideline for clinical application of renal mpMRI.
Authors
- Zhigang Wu (ORCID: https://orcid.org/0000-0001-5117-8480)
- Yanqiu Feng (ORCID: https://orcid.org/0000-0002-2807-5974)
- Ziqi An (ORCID: https://orcid.org/0000-0002-8544-8749)
- Zelong Chen
- Tao Quan (ORCID: https://orcid.org/0000-0002-5056-7123)
- Kan Deng (ORCID: https://orcid.org/0000-0001-9571-3705)
- Qianqian Zhang (ORCID: https://orcid.org/0000-0002-0735-451X)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4723
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00