Decoding the anti-hypertensive mechanism of α-mangostin based on network pharmacology, molecular docking and experimental validation
Our analyses showed that TNF, HSP90AA1, NFKB1, PPARG, SIRT1, PTGS2, and RELA might be α-MG's potential therapeutic targets for hypertension, laying groundwork for further investigation into its pharmacological mechanisms and clinical uses.
Authors
- Qiqi Xue (ORCID: https://orcid.org/0000-0002-9634-9658)
- Yan Li (ORCID: https://orcid.org/0000-0002-2933-7673)
- Chu‐Hao Liu (ORCID: https://orcid.org/0009-0006-9881-4599)
Institutions
- Ruijin Hospital (CN)
- Shanghai Institute of Hypertension (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1186/s10020-024-01001-8
- Citations
- 7
- Primary Topic
- Mangiferin and Mango Extracts
- Type
- article
- Field-Weighted Citation Impact
- 5.01
Funders
- National Natural Science Foundation of China